144059-86-9
![4-Methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole-5-carboxylic acid Chemical Structure](http://file.medchemexpress.cn/product_pic/hy-w158239.gif "4-Methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole-5-carboxylic acid Chemical Structure")
144059-86-9
Chemical Structure
4-Methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole-5-carboxylic acid
- CAS No.: 144059-86-9
- Formula:C12H8F3NO2S
- Molecular Weight:287.26
IUPAC Name: 4-methyl-2-(4-(trifluoromethyl)phenyl)thiazole-5-carboxylic acid
InChIKey: DRFFZMPSUPHSJN-UHFFFAOYSA-N
SMILES: CC1=C(C(=O)O)SC(=N1)C2=CC=C(C=C2)C(F)(F)F
Biological Activity: 4-Methyl-2-[4-(trifluoromethyl) phenyl]-1,3-thiazole-5-carboxylic acid is a substituted thiazole carboxylic acid synthetic intermediate and a metabolite of GW 501516 (HY-10838), which is detected in horse plasma and hair samples after administration[1][2].
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4-Methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole-5-carboxylic acid | 4-Methyl-2-[4-(trifluoromethyl) phenyl]-1,3-thiazole-5-carboxylic acid is a substituted thiazole carboxylic acid synthetic intermediate and a metabolite of GW 501516 (HY-10838), which is detected in horse plasma and hair samples after administration. | |||||||||||||||||||||
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References
- [1]. Sierra ML, et al. Substituted 2-[(4-aminomethyl)phenoxy]-2-methylpropionic acid PPARalpha agonists. 1. Discovery of a novel series of potent HDLc raising agents. Journal of medicinal chemistry. 2007 Feb 22;50(4):685-95. [Content Brief]
- [2]. Ishii H, et al. Detection and longitudinal distribution of GW1516 and its metabolites in equine hair for doping control using liquid chromatography/high-resolution mass spectrometry. Rapid communications in mass spectrometry : RCM. 2021 Apr 30;35(8):e9050.
