1443994-98-6
1443994-98-6
Chemical Structure
Mongersen sodium
Synonym(s): GED-0301 sodium
- CAS No.: 1443994-98-6
- Formula:C200H241N69O107P20S20Na20
- Molecular Weight:6604 (free acid)
SMILES: [Mongersen (sodium)]
Biological Activity: Mongersen sodium is a specific and orally active SMAD7 antisense oligonucleotide. Mongersen sodium restores TGF-β1 activity leading to inhibition of inflammatory signals. Mongersen sodium can attenuate Crohn's disease-like experimental colitis in mice[1][2].
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Mongersen sodium | 99.61% | Mongersen sodium is a specific and orally active SMAD7 antisense oligonucleotide. Mongersen sodium restores TGF-β1 activity leading to inhibition of inflammatory signals. Mongersen sodium can attenuate Crohn's disease-like experimental colitis in mice. | ||||||||||||||||||||
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References
- [1]. Monteleone G, et, al. Mongersen, an oral SMAD7 antisense oligonucleotide, and Crohn's disease. N Engl J Med. 2015 Mar 19;372(12):1104-13. [Content Brief]
- [2]. Izzo R, et, al. Knockdown of Smad7 With a Specific Antisense Oligonucleotide Attenuates Colitis and Colitis-Driven Colonic Fibrosis in Mice. Inflamm Bowel Dis. 2018 May 18;24(6):1213-1224. [Content Brief]
Keywords
