144860-70-8
Chemical Structure
Reveromycin D
- CAS No.: 144860-70-8
- Formula:
- Molecular Weight:674.82
IUPAC Name: (2E,4S,5S,6E,8E)-10-((2R,3S,6S,8R,10S)-8-((1E,3E)-4-carboxy-3-methylbuta-1,3-dien-1-yl)-10-((3-carboxypropanoyl)oxy)-3-methyl-10-pentyl-1,7-dioxaspiro[5.5]undecan-2-yl)-5-hydroxy-4,8-dimethyldeca-2,6,8-trienoic acid
InChIKey: LAYXXMUMPHOKOM-RCSQVYJHSA-N
SMILES: CCCCC[C@@]1(C[C@@H](O[C@@]2(C1)CC[C@@H]([C@H](O2)C/C=C(\C)/C=C/[C@@H]([C@@H](C)/C=C/C(=O)O)O)C)/C=C/C(=C/C(=O)O)/C)OC(=O)CCC(=O)O
Biological Activity: Reveromycin D is a bacterial metabolite originally isolated from Streptomyces. It inhibits EGF-induced mitogenic activity in Balb/MK cells and has pH-dependent antifungal activity against C. albicans (MICs=2 and >500 μg/mL at pH 3 and 7.4, respectively).2 Reveromycin D also inhibits proliferation of KB and K562 cells (IC50s=1.6 and 1.3 μg/mL, respectively).
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Reveromycin D | Reveromycin D is a bacterial metabolite originally isolated from Streptomyces. It inhibits EGF-induced mitogenic activity in Balb/MK cells and has pH-dependent antifungal activity against C. albicans (MICs=2 and >500 μg/mL at pH 3 and 7.4, respectively).2 Reveromycin D also inhibits proliferation of KB and K562 cells (IC50s=1.6 and 1.3 μg/mL, respectively). | |||||||||||||||||||||
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Keywords
