144966-96-1
Chemical Structure
Adatanserin hydrochloride
Synonym(s): WY-50324 hydrochloride; SEB-324 hydrochloride
- CAS No.: 144966-96-1
- Formula:C21H32ClN5O
- Molecular Weight:405.96
IUPAC Name: N-(2-(4-(pyrimidin-2-yl)piperazin-1-yl)ethyl)adamantane-1-carboxamide hydrochloride
InChIKey: PPHCXMVJHQJEAK-UHFFFAOYSA-N
SMILES: O=C(C1(C2)CC3CC2CC(C3)C1)NCCN4CCN(C5=NC=CC=N5)CC4.Cl
Biological Activity: Adatanserin hydrochloride is a high affinity, selective and partial agonist for the 5-HT1A receptor with a Ki of 1 nM. Adatanserin hydrochloride is a moderate affinity 5-HT2 receptor antagonist with a Ki of 73 nM. Adatanserin hydrochloride shows significant anxiolytic and antidepressant activity in an animal conflict model[1][2].
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Adatanserin hydrochloride | Adatanserin hydrochloride is a high affinity, selective and partial agonist for the 5-HT1A receptor with a Ki of 1 nM. Adatanserin hydrochloride is a moderate affinity 5-HT2 receptor antagonist with a Ki of 73 nM. Adatanserin hydrochloride shows significant anxiolytic and antidepressant activity in an animal conflict model. | |||||||||||||||||||||
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References
- [1]. M A Abou-Gharbia, et al. Synthesis and SAR of adatanserin: novel adamantyl aryl- and heteroarylpiperazines with dual serotonin 5-HT(1A) and 5-HT(2) activity as potential anxiolytic and antidepressant agents. [Content Brief]
- [2]. A Singh, et al. Antidepressant-like activity of compounds with varying efficacy at 5-HT1A receptors. Neuropharmacology. 1993 Apr;32(4):331-40. [Content Brief]
