1451362-51-8
Chemical Structure
CbzNH-PEG4-CH2COOH
- CAS No.: 1451362-51-8
- Formula:C18H27NO8
- Molecular Weight:385.41
IUPAC Name: 3-oxo-1-phenyl-2,7,10,13,16-pentaoxa-4-azaoctadecan-18-oic acid
InChIKey: CSUBNGPYLDOHIP-UHFFFAOYSA-N
SMILES: O=C(O)COCCOCCOCCOCCNC(=O)OCC1=CC=CC=C1
Biological Activity: CbzNH-PEG4-CH2COOH is a PEG linker containing an carboxylic acid (CO2H) group and a benzyl (Cbz) protecting group. The hydrophilic PEG spacer increases the water solubility of a compound in aqueous media. The terminal carboxylic acid is reactive with primary amine groups in the presence of activators (e.g. HATU) forming a stable amide bond. The benzyl protecting group can be removed via hydrogenolysis to form a free amine.
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CbzNH-PEG4-CH2COOH | CbzNH-PEG4-CH2COOH is a PEG linker containing an carboxylic acid (CO2H) group and a benzyl (Cbz) protecting group. The hydrophilic PEG spacer increases the water solubility of a compound in aqueous media. The terminal carboxylic acid is reactive with primary amine groups in the presence of activators (e.g. HATU) forming a stable amide bond. The benzyl protecting group can be removed via hydrogenolysis to form a free amine. | |||||||||||||||||||||
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