147776-06-5
147776-06-5
Chemical Structure
L-161982
- CAS No.: 147776-06-5
- Formula:C32H29F3N4O4S2
- Molecular Weight:654.72
IUPAC Name: N-((4'-((3-butyl-5-oxo-1-(2-(trifluoromethyl)phenyl)-1,5-dihydro-4H-1,2,4-triazol-4-yl)methyl)-[1,1'-biphenyl]-2-yl)sulfonyl)-3-methylthiophene-2-carboxamide
InChIKey: MMDNKTXNUZFVKD-UHFFFAOYSA-N
SMILES: O=C(C1=C(C)C=CS1)NS(=O)(C2=CC=CC=C2C3=CC=C(CN4C(CCCC)=NN(C5=CC=CC=C5C(F)(F)F)C4=O)C=C3)=O
Biological Activity: L-161982 is a selective EP4 receptor antagonist. L-161982 completely blocks PGE2-induced ERK phosphorylation and cell proliferation of HCA-7 cells. L-161982 alleviates collagen-induced arthritis in mice[1][2].
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L-161982 | 99.33% | L-161982 is a selective EP4 receptor antagonist. L-161982 completely blocks PGE2-induced ERK phosphorylation and cell proliferation of HCA-7 cells. L-161982 alleviates collagen-induced arthritis in mice. | ||||||||||||||||||||
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L-161982 (Standard) | ≥98% | L-161982 (Standard) is the analytical standard of L-161982. This product is intended for research and analytical applications. L-161982 is a selective EP4 receptor antagonist. L-161982 completely blocks PGE2-induced ERK phosphorylation and cell proliferation of HCA-7 cells. L-161982 alleviates collagen-induced arthritis in mice. | ||||||||||||||||||||
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References
- [1]. Li X, et al.The EP4 antagonist, L-161,982, induces apoptosis, cell cycle arrest, and inhibits prostaglandin E2-induced proliferation in oral squamous carcinoma Tca8113 cells.J Oral Pathol Med. 2017 Nov;46(10):991-997. [Content Brief]
- [2]. Cherukuri DP, et al. The EP4 receptor antagonist, L-161,982, blocks prostaglandin E2-induced signal transduction and cell proliferation in HCA-7 colon cancer cells.Exp Cell Res. 2007 Aug 15;313(14):2969-79. [Content Brief]
