148152-66-3
148152-66-3
Chemical Structure
(±)-Epibatidine
Synonym(s): CMI 545
- CAS No.: 148152-66-3
- Formula:C11H13ClN2
- Molecular Weight:208.69
IUPAC Name: (1S,2S,4R)-2-(6-chloropyridin-3-yl)-7-azabicyclo[2.2.1]heptane
InChIKey: NLPRAJRHRHZCQQ-UTLUCORTSA-N
SMILES: ClC1=CC=C([C@H]2[C@@H](N3)CC[C@@H]3C2)C=N1
Biological Activity: (±)-Epibatidine (CMI 545) is a neuronal nicotinic acetylcholine receptor (nAChR) agonist that targets brain nicotinic receptors, thereby inhibiting afferent micturition pathways and sensory pathways, consequently suppressing the micturition reflex and mediating antihyperalgesic effects. (±)-Epibatidine can be used in the study of trigeminal neuralgia[1][2].
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(±)-Epibatidine | (±)-Epibatidine (CMI 545) is a neuronal nicotinic acetylcholine receptor (nAChR) agonist that targets brain nicotinic receptors, thereby inhibiting afferent micturition pathways and sensory pathways, consequently suppressing the micturition reflex and mediating antihyperalgesic effects. (±)-Epibatidine can be used in the study of trigeminal neuralgia. | |||||||||||||||||||||
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References
- [1]. Lee SJ, et al. Effect of (+/-)-epibatidine, a nicotinic agonist, on the central pathways controlling voiding function in the rat. American journal of physiology. Regulatory, integrative and comparative physiology. 2003 Jul;285(1):R84-90. [Content Brief]
- [2]. Gilbert SD, et al. Antihyperalgesic activity of epibatidine in the formalin model of facial pain. Pain. 2001 Jan;89(2-3):159-65.
