148966-66-9
Chemical Structure
LY86057
- CAS No.: 148966-66-9
- Formula:C20H26N2O3
- Molecular Weight:342.43
IUPAC Name: 3-hydroxybutan-2-yl (6aR,9R,10aR)-7-methyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline-9-carboxylate
InChIKey: GOHDSZGHAHFEHG-JZLGIKSISA-N
SMILES: CN1[C@@]2([H])[C@@](C[C@H](C1)C(OC(C)C(O)C)=O)([H])C3=CC=CC4=C3C(C2)=CN4
Biological Activity: LY86057 is an ergoline derivative without N1 substituents. It has higher affinity for porcine, squirrel monkey and human 5-HT2 receptors than rats and is an antagonist of 5-HT2 receptors. When studying the differences in recognition of a series of ergolines between species, LY86057 was found to be more selective for 5-HT2 receptors. Compared with LY53857, LY108742 resulted in a higher affinity for rat 5-HT2 receptors even when the N1 substituent was only methyl.
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LY86057 | LY86057 is an ergoline derivative without N1 substituents. It has higher affinity for porcine, squirrel monkey and human 5-HT2 receptors than rats and is an antagonist of 5-HT2 receptors. When studying the differences in recognition of a series of ergolines between species, LY86057 was found to be more selective for 5-HT2 receptors. Compared with LY53857, LY108742 resulted in a higher affinity for rat 5-HT2 receptors even when the N1 substituent was only methyl. | |||||||||||||||||||||
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Keywords
