149064-34-6
Chemical Structure
Pycnidione
- CAS No.: 149064-34-6
- Formula:C33H40O7
- Molecular Weight:548.67
InChIKey: BWTQHPFSWXJOGP-MDEGSHASSA-N
SMILES: C[C@@]12[C@](CC(C)(/C=C\C[C@]3([C@](CC4=C(C=C(C(C=C4C)=O)O)O3)([H])C[C@H]2O)C)C)([H])CC5=C(C=C(C(C=C5C)=O)O)O1
Biological Activity: Pycnidione is a natural small-molecule compound isolated from fungi. Pycnidione inhibits stromelysin/MMP3, targets cyclin D1/E, induces G1 phase arrest, modulates survivin, affects caspase-8/3, targets PAI-1, inhibits topoisomerases, and induces HIF-1α accumulation/nuclear translocation and DNA binding/reporter gene transactivation and erythropoietin expression. Pycnidione induces apoptosis, reactive oxygen species (ROS) generation, and mitochondrial membrane potential collapse. Pycnidione can be used for research on lung cancer[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Pycnidione | Pycnidione is a natural small-molecule compound isolated from fungi. Pycnidione inhibits stromelysin/MMP3, targets cyclin D1/E, induces G1 phase arrest, modulates survivin, affects caspase-8/3, targets PAI-1, inhibits topoisomerases, and induces HIF-1α accumulation/nuclear translocation and DNA binding/reporter gene transactivation and erythropoietin expression. Pycnidione induces apoptosis, reactive oxygen species (ROS) generation, and mitochondrial membrane potential collapse. Pycnidione can be used for research on lung cancer. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Hsiao CJ, et al. Pycnidione, a fungus-derived agent, induces cell cycle arrest and apoptosis in A549 human lung cancer cells. Chemico-biological interactions. 2012 Apr 15;197(1):23-30.
- [2]. Bemis CY, et al. Total Synthesis and Computational Investigations of Sesquiterpene-Tropolones Ameliorate Stereochemical Inconsistencies and Resolve an Ambiguous Biosynthetic Relationship. Journal of the American Chemical Society. 2021 Apr 21;143(15):6006-6017.
