1501974-69-1
Chemical Structure
MGS0274
- CAS No.: 1501974-69-1
- Formula:C21H32FNO7
- Molecular Weight:429.48
IUPAC Name: (1S,2S,3S,5R,6S)-2-amino-3-fluoro-6-(((S)-1-(((((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)oxy)carbonyl)oxy)ethoxy)carbonyl)bicyclo[3.1.0]hexane-2-carboxylic acid
InChIKey: IPAZEPBIOFZFEF-UZEWAWMVSA-N
SMILES: O=C([C@@]1(N)[C@]2([H])[C@@H](C(O[C@@H](OC(O[C@H]3[C@H](C(C)C)CC[C@@H](C)C3)=O)C)=O)[C@]2([H])C[C@@H]1F)O
Biological Activity: MGS0274, an ester-based lipophilic proagent of a metabotropic glutamate (mGlu)2 and mGlu3 receptor agonist MGS0008, shows improved oral bioavailability. MGS0274 has the potential for the research of schizophrenia[1][2].
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MGS0274 | MGS0274, an ester-based lipophilic proagent of a metabotropic glutamate (mGlu)2 and mGlu3 receptor agonist MGS0008, shows improved oral bioavailability. MGS0274 has the potential for the research of schizophrenia. | |||||||||||||||||||||
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- [1]. Urabe H, et al. Discovery of MGS0274, an ester prodrug of a metabotropic glutamate receptor 2/3 agonist with improved oral bioavailability [published online ahead of print, 2020 Jul 5]. Eur J Med Chem. 2020;203:112521. [Content Brief]
- [2]. Kinoshita K, et al. Preclinical disposition of MGS0274 besylate, a prodrug of a potent group II metabotropic glutamate receptor agonist MGS0008 for the treatment of schizophrenia. Pharmacol Res Perspect. 2019;7(5):e00520. Published 2019 Sep 13. [Content Brief]
Keywords
