150323-78-7
Chemical Structure
Quipazine dimaleate
- CAS 番号: 150323-78-7
- Formula:C21H23N3O8
- Molecular Weight:445.42
IUPAC Name: 2-(piperazin-1-yl)quinoline dimaleate
InChIKey: VAOSOCRJSSWBEQ-SPIKMXEPSA-N
SMILES: O=C(O)/C=C\C(O)=O.O=C(O)/C=C\C(O)=O.C1(N2CCNCC2)=NC3=CC=CC=C3C=C1
Biological Activity: Quipazine dimaleate is a 5-HT agonist with a Ki value of 1.4 nM for displaces [3H]GR65630 from 5-HT3R in rat. Quipazine dimaleate shows antiviral activity against SARS-CoV-2 with an EC50 of 31.64 μM. Quipazine dimaleate behaves as a 5-HT3R antagonist in peripheral models. Quipazine dimaleate can be used for neurological disease research[1][2][3][4].
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Quipazine dimaleate | 99.96% | Quipazine dimaleate is a 5-HT agonist with a Ki value of 1.4 nM for displaces [3H]GR65630 from 5-HT3R in rat. Quipazine dimaleate shows antiviral activity against SARS-CoV-2 with an EC50 of 31.64 μM. Quipazine dimaleate behaves as a 5-HT3R antagonist in peripheral models. Quipazine dimaleate can be used for neurological disease research. | ||||||||||||||||||||
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- [1]. Mok E, et al. Effect of quipazine, a selective 5-HT3 agonist, on dietary self-selection of different macronutrient diets in male and female rats. Appetite. 2000 Jun;34(3):313-25. [Content Brief]
- [2]. Günther S, et al. X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease. Science. 2021 May 7;372(6542):642-646. [Content Brief]
- [3]. Glennon RA, et al. 5-HT1 and 5-HT2 binding characteristics of some quipazine analogues. J Med Chem. 1986 Nov;29(11):2375-80. [Content Brief]
- [4]. Ireland SJ, Tyers MB. Pharmacological characterization of 5-hydroxytryptamine-induced depolarization of the rat isolated vagus nerve. Br J Pharmacol. 1987 Jan;90(1):229-38. [Content Brief]
Keywords
