1508250-72-3
1508250-72-3
Chemical Structure
Nazartinib mesylate
Synonym(s): EGF816 mesylate
- CAS No.: 1508250-72-3
- Formula:C27H35ClN6O5S
- Molecular Weight:591.12
IUPAC Name: (R,E)-N-(7-chloro-1-(1-(4-(dimethylamino)but-2-enoyl)azepan-3-yl)-1H-benzo[d]imidazol-2-yl)-2-methylisonicotinamide methanesulfonate
InChIKey: BJRYTAMUVASSBY-ZJULCNDBSA-N
SMILES: O=C(C1=CC(C)=NC=C1)NC2=NC3=CC=CC(Cl)=C3N2[C@H]4CN(C(/C=C/CN(C)C)=O)CCCC4.CS(=O)(O)=O
Biological Activity: Nazartinib mesylate (EGF816 mesylate) is a novel, covalent mutant-selective EGFR inhibitor, with Ki and Kinact of 31 nM and 0.222 min−1 on EGFR(L858R/790M) mutant, respectively.
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Nazartinib mesylate | Nazartinib mesylate (EGF816 mesylate) is a novel, covalent mutant-selective EGFR inhibitor, with Ki and Kinact of 31 nM and 0.222 min−1 on EGFR(L858R/790M) mutant, respectively. | |||||||||||||||||||||
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Keywords
