1513855-74-7
![N6-[[(4-Azidophenyl)methoxy]carbonyl]-L-lysine Chemical Structure](http://file.medchemexpress.cn/product_pic/hy-154835.gif "N6-[[(4-Azidophenyl)methoxy]carbonyl]-L-lysine Chemical Structure")
Chemical Structure
N6-[[(4-Azidophenyl)methoxy]carbonyl]-L-lysine
- CAS No.: 1513855-74-7
- Formula:C14H19N5O4
- Molecular Weight:321.33
IUPAC Name: N6-(((4-azidobenzyl)oxy)carbonyl)-L-lysine
InChIKey: TZQHUQASIQQHCK-LBPRGKRZSA-N
SMILES: N[C@@H](CCCCNC(OCC1=CC=C(N=[N+]=[N-])C=C1)=O)C(O)=O
Biological Activity: N6-[[(4-Azidophenyl)methoxy]carbonyl]-L-lysine is an unnatural lysine analog and a substrate of the PABKRS mutant PylRS. N6-[[(4-Azidophenyl)methoxy]carbonyl]-L-lysine enables site-specific genetic integration into proteins via amber stop codon suppression; it undergoes Staudinger reduction with phosphine compounds, followed by a self-elimination reaction to release native lysine. N6-[[(4-Azidophenyl)methoxy]carbonyl]-L-lysine serves as a genetically encoded element for the temporal chemical control of protein SUMOylation and nuclear translocation in living mammalian cells, and also acts as a bioorthogonal reaction handle for bioconjugation reactions[1].
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N6-[[(4-Azidophenyl)methoxy]carbonyl]-L-lysine | N6-[[(4-Azidophenyl)methoxy]carbonyl]-L-lysine is an unnatural lysine analog and a substrate of the PABKRS mutant PylRS. N6-[[(4-Azidophenyl)methoxy]carbonyl]-L-lysine enables site-specific genetic integration into proteins via amber stop codon suppression; it undergoes Staudinger reduction with phosphine compounds, followed by a self-elimination reaction to release native lysine. N6-[[(4-Azidophenyl)methoxy]carbonyl]-L-lysine serves as a genetically encoded element for the temporal chemical control of protein SUMOylation and nuclear translocation in living mammalian cells, and also acts as a bioorthogonal reaction handle for bioconjugation reactions. | |||||||||||||||||||||
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