153345-74-5
Chemical Structure
DMP-728 free base
Synonym(s): XL-118
- CAS No.: 153345-74-5
- Formula:C25H36N8O7
- Molecular Weight:560.60
SMILES: O=C1C2=CC(CNC([C@@H](NC(CNC([C@@H](N(C([C@H](N1)CC)=O)C)CCCNC(N)=N)=O)=O)CC(O)=O)=O)=CC=C2
Biological Activity: DMP-728 free base (XL-118) is a highly potent and selective GPIIb/IIIa antagonist with antiplatelet and antithrombotic activities. DMP-728 free base can inhibit ADP-induced human platelet aggregation in vitro, with an IC50 of 46 nmol/L, and can significantly reduce the interaction between fibrinogen and human platelets or Binding of purified human GPIIb/IIIa receptors. DMP-728 free base exhibits dose-dependent antiplatelet effects in anesthetized mongrel dogs, effectively inhibiting ADP-induced platelet aggregation and prolonging template bleeding time[1].
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DMP-728 free base | DMP-728 free base (XL-118) is a highly potent and selective GPIIb/IIIa antagonist with antiplatelet and antithrombotic activities. DMP-728 free base can inhibit ADP-induced human platelet aggregation in vitro, with an IC50 of 46 nmol/L, and can significantly reduce the interaction between fibrinogen and human platelets or Binding of purified human GPIIb/IIIa receptors. DMP-728 free base exhibits dose-dependent antiplatelet effects in anesthetized mongrel dogs, effectively inhibiting ADP-induced platelet aggregation and prolonging template bleeding time. | |||||||||||||||||||||
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