154229-20-6
154229-20-6
Chemical Structure
Anhydro abiraterone
- CAS No.: 154229-20-6
- Formula:C24H29N
- Molecular Weight:331.49
IUPAC Name: 3-((8R,9S,10R,13S,14S)-10,13-dimethyl-2,7,8,9,10,11,12,13,14,15-decahydro-1H-cyclopenta[a]phenanthren-17-yl)pyridine
InChIKey: LAZGFPQCCUTDPH-NHFPKVKZSA-N
SMILES: C[C@@]1(C(C2=CN=CC=C2)=CC3)[C@]3([H])[C@@](CC=C4[C@@]5(CCC=C4)C)([H])[C@]5([H])CC1
Biological Activity: Anhydro abiraterone is a degradation product of Abiraterone acetate (HY-75054). Abiraterone acetate (CB7630) is an oral, potent, selective, and irreversible inhibitor of CYP17A1 with antiandrogen activity[1][2].
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Anhydro abiraterone | Anhydro abiraterone is a degradation product of Abiraterone acetate (HY-75054). Abiraterone acetate (CB7630) is an oral, potent, selective, and irreversible inhibitor of CYP17A1 with antiandrogen activity. | |||||||||||||||||||||
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References
- [1]. Deepak Krishna Mhaske, et al. The first RP-UHPLC method for simultaneous quantification of abiraterone acetate, its four degradants, and six specified process impurities and correct identification of all analytes based on molecular weight. J Pharm Biomed Anal. 2023 Sep 20:234:115568. [Content Brief]
- [2]. Stein MN, et al. Androgen synthesis inhibitors in the treatment of castration-resistant prostate cancer. Asian J Androl. 2014 May-Jun;16(3):387-400. [Content Brief]
