154235-77-5
Chemical Structure
Serpin B9-IN-1
Synonym(s): BTCA
- CAS No.: 154235-77-5
- Formula:C8H5NO3
- Molecular Weight:163.13
IUPAC Name: benzo[d]oxazole-6-carboxylic acid
InChIKey: FRNTUFQKHQMLSE-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C2N=COC2=C1)O
Biological Activity: Serpin B9-IN-1 (BTCA) is an inhibitor that specifically targets Serpin B9 (SB9); SB9 is a natural inhibitor of granzyme B (GrB) , but may promote the metastasis of lung cancer cells into the bone marrow. SB9-overexpressing cancer cells promote proliferation and metastasis in an immune cell-dependent manner by binding to GrB. Inhibition of SB9 by Serpin B9-IN-1 significantly inhibits immunotherapy of lung cancer bone metastases in the caudal artery (CA) mouse model (LCBM)[1].
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Serpin B9-IN-1 | 97.42% | Serpin B9-IN-1 (BTCA) is an inhibitor that specifically targets Serpin B9 (SB9); SB9 is a natural inhibitor of granzyme B (GrB) , but may promote the metastasis of lung cancer cells into the bone marrow. SB9-overexpressing cancer cells promote proliferation and metastasis in an immune cell-dependent manner by binding to GrB. Inhibition of SB9 by Serpin B9-IN-1 significantly inhibits immunotherapy of lung cancer bone metastases in the caudal artery (CA) mouse model (LCBM). | ||||||||||||||||||||
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