154355-76-7
Chemical Structure
Atreleuton
Synonym(s): ABT-761; VIA-2291
- CAS No.: 154355-76-7
- Formula:C16H15FN2O2S
- Molecular Weight:318.37
IUPAC Name: (R)-1-(4-(5-(4-fluorobenzyl)thiophen-2-yl)but-3-yn-2-yl)-1-hydroxyurea
InChIKey: MMSNEKOTSJRTRI-LLVKDONJSA-N
SMILES: O=C(N)N([C@H](C)C#CC1=CC=C(CC2=CC=C(F)C=C2)S1)O
Biological Activity: Atreleuton (ABT-761) is a selective, reversible, and orally bioavailable 5-Lipoxygenase (5-LO) inhibitor. Atreleuton (ABT-761) exhibits potent and selective inhibition of leukotriene formation[1][2][3]. Atreleuton is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
| Cat. No. | 상품명 | Purity | 제품 설명 | Pricing | |||||||||||||||||||
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Atreleuton | 99.9% | Atreleuton (ABT-761) is a selective, reversible, and orally bioavailable 5-Lipoxygenase (5-LO) inhibitor. Atreleuton (ABT-761) exhibits potent and selective inhibition of leukotriene formation. Atreleuton is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | ||||||||||||||||||||
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Atreleuton-d4 | Atreleuton-d4 (ABT-761-d4; VIA-2291-d4) is deuterium-labeled Atreleuton (HY-117853). | |||||||||||||||||||||
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- [1]. VIA Pharmaceuticals Meets With FDA to Discuss Next Steps For VIA-2291 and Phase 3 Outcome Trial in Cardiovascular Disease. VIA Pharmaceuticals, Inc.
- [2]. Reid JJ, et al. ABT-761 (Abbott). Curr Opin Investig Drugs. 2001 Jan;2(1):68-71. [Content Brief]
- [3]. Bell RL, et al. ABT-761 attenuates bronchoconstriction and pulmonary inflammation in rodents. J Pharmacol Exp Ther. 1997 Mar;280(3):1366-73. [Content Brief]
Keywords
