15465-92-6
Chemical Structure
2-Chloro-6-methoxypurine riboside
Synonym(s): 2-Chloro-6-O-methyl-inosine
- CAS No.: 15465-92-6
- Formula:C11H13ClN4O5
- Molecular Weight:316.70
IUPAC Name: (2R,3R,4S,5R)-2-(2-chloro-6-methoxy-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
InChIKey: QFGKCCNEHWKCTD-KQYNXXCUSA-N
SMILES: OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(N=C(Cl)N=C3OC)=C3N=C2)O1
Biological Activity: 2-Chloro-6-methoxypurine riboside is a hypoxanthine analog. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia[1][2].
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2-Chloro-6-methoxypurine riboside | 2-Chloro-6-methoxypurine riboside is a hypoxanthine analog. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia. | |||||||||||||||||||||
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- [1]. Virág L, Szabó C. Purines inhibit poly(ADP-ribose) polymerase activation and modulate oxidant-induced cell death. FASEB J. 2001 Jan;15(1):99-107. [Content Brief]
- [2]. Saugstad OD. Hypoxanthine as an indicator of hypoxia: its role in health and disease through free radical production. Pediatr Res. 1988 Feb;23(2):143-50. [Content Brief]
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