15687-16-8
15687-16-8
Chemical Structure
Carbiphene
- CAS. Nr.: 15687-16-8
- Formula:C28H34N2O2
- Molecular Weight:430.59
IUPAC Name: 2-ethoxy-N-methyl-N-(2-(methyl(phenethyl)amino)ethyl)-2,2-diphenylacetamide
InChIKey: NQIZDFMZAXUZCZ-UHFFFAOYSA-N
SMILES: O=C(N(C)CCN(C)CCC=1C=CC=CC1)C(OCC)(C=2C=CC=CC2)C=3C=CC=CC3
Biological Activity: Carbiphene is a GABAA receptor allosteric modulator. Carbiphene inhibits [35S] TBPS binding and enhances [3H] muscimol binding on rat forebrain membranes, acting on specific GABAA receptor subsets. Carbiphene can be used in research related to schizophrenia[1].
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Carbiphene | Carbiphene is a GABAA receptor allosteric modulator. Carbiphene inhibits [35S] TBPS binding and enhances [3H] muscimol binding on rat forebrain membranes, acting on specific GABAA receptor subsets. Carbiphene can be used in research related to schizophrenia. | |||||||||||||||||||||
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References
- [1]. Squires RF, et al. Additivities of compounds that increase the numbers of high affinity [3H]muscimol binding sites by different amounts define more than 9 GABA(A) receptor complexes in rat forebrain: implications for schizophrenia and clozapine research. Neurochem Res. 2000;25(12):1587-1601. [Content Brief]
