156951-82-5
156951-82-5
Chemical Structure
Chrysotoxine
- CAS No.: 156951-82-5
- Formula:C18H22O5
- Molecular Weight:318.36
IUPAC Name: 4-(3,4-dimethoxyphenethyl)-2,6-dimethoxyphenol
InChIKey: YUHRVKGYFHPWRI-UHFFFAOYSA-N
SMILES: OC1=C(C=C(C=C1OC)CCC2=CC=C(C(OC)=C2)OC)OC
Biological Activity: Chrysotoxine is a dual inhibitor of Src/Akt. Chrysotoxine suppresses cancer stem cells (CSCs) phenotypes by down-regulating Src/Akt signaling. Chrysotoxine reduces cell viability and increases apoptosis level in H460 and H23 cells instead of non-tumor cell lines. Chrysotoxine shows rapid excretion and low bioavailability in rats. Chrysotoxine is used in cancer research[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Chrysotoxine | 99.52% | Chrysotoxine is a dual inhibitor of Src/Akt. Chrysotoxine suppresses cancer stem cells (CSCs) phenotypes by down-regulating Src/Akt signaling. Chrysotoxine reduces cell viability and increases apoptosis level in H460 and H23 cells instead of non-tumor cell lines. Chrysotoxine shows rapid excretion and low bioavailability in rats. Chrysotoxine is used in cancer research. | ||||||||||||||||||||
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References
- [1]. Bhummaphan N, et al. Cancer Stem Cell-Suppressing Activity of Chrysotoxine, a Bibenzyl from Dendrobium pulchellum. J Pharmacol Exp Ther. 2018 Feb;364(2):332-346. [Content Brief]
- [2]. Fan J, et al. Determination of chrysotoxine in rat plasma by liquid chromatography-tandem mass spectrometry and its application to a rat pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Sep 15;967:57-62. [Content Brief]
