157182-23-5
Chemical Structure
Metesind glucuronate
Synonym(s): AG 331
- CAS No.: 157182-23-5
- Formula:C29H34N4O10S
- Molecular Weight:630.67
IUPAC Name: N6-methyl-N6-(4-(morpholinosulfonyl)benzyl)benzo[cd]indole-2,6-diamine (2S,3S,4S,5R)-2,3,4,5-tetrahydroxy-6-oxohexanoate
InChIKey: WGYHOPIXAFLRPR-LRDBBFHQSA-N
SMILES: O=C[C@@H]([C@H]([C@@H]([C@@H](C(O)=O)O)O)O)O.O=S(N1CCOCC1)(C2=CC=C(CN(C3=CC=C4N=C(N)C5=CC=CC3=C54)C)C=C2)=O
Biological Activity: Metesind glucuronate (AG 331) is an inhibitor for thymidylate synthase with Ki of 1.2 nM. Metesind glucuronate inhibits the DNA synthesis and thus inhibits the cell viability of cancer cells with IC50 of 0.4-0.9 μM[1].
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Metesind glucuronate | Metesind glucuronate (AG 331) is an inhibitor for thymidylate synthase with Ki of 1.2 nM. Metesind glucuronate inhibits the DNA synthesis and thus inhibits the cell viability of cancer cells with IC50 of 0.4-0.9 μM. | |||||||||||||||||||||
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Keywords
