158890-32-5
Chemical Structure
GSTO1-IN-3
- CAS No.: 158890-32-5
- Formula:C14H18ClNO
- Molecular Weight:251.75
IUPAC Name: 1-(4-benzylpiperidin-1-yl)-2-chloroethan-1-one
InChIKey: NESGURPSHDOKFU-UHFFFAOYSA-N
SMILES: O=C(N1CCC(CC1)CC2=CC=CC=C2)CCl
Biological Activity: GSTO1-IN-3 is a potent GSTO1-1 inhibitor with an IC50 of 0.11 μM, and shows selectivity over GSTO2-2, GSTA1-1 and GSTP1-1 (IC50 > 100 μM). GSTO1-IN-3 enhances the cytotoxicity of Cisplatin (HY-17394) against human breast cancer cells. GSTO1-IN-3 inhibits IL-1β release in mouse bone marrow-derived macrophage (BMDM) cells. GSTO1-IN-3 attenuates inflammation in mice. GSTO1-IN-3 can be used for breast cancer and inflammation research[1].
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GSTO1-IN-3 | GSTO1-IN-3 is a potent GSTO1-1 inhibitor with an IC50 of 0.11 μM, and shows selectivity over GSTO2-2, GSTA1-1 and GSTP1-1 (IC50 > 100 μM). GSTO1-IN-3 enhances the cytotoxicity of Cisplatin (HY-17394) against human breast cancer cells. GSTO1-IN-3 inhibits IL-1β release in mouse bone marrow-derived macrophage (BMDM) cells. GSTO1-IN-3 attenuates inflammation in mice. GSTO1-IN-3 can be used for breast cancer and inflammation research. | |||||||||||||||||||||
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Keywords
