160521-72-2
160521-72-2
Chemical Structure
BW-723C86
- CAS No.: 160521-72-2
- Formula:C16H19ClN2OS
- Molecular Weight:322.85
IUPAC Name: 1-(5-(thiophen-2-ylmethoxy)-1H-indol-3-yl)propan-2-amine hydrochloride
InChIKey: PYJBJMIBANAOFJ-UHFFFAOYSA-N
SMILES: NC(C)CC1=CNC2=C1C=C(OCC3=CC=CS3)C=C2.Cl
Biological Activity: BW-723C86 is an orally active and a selective 5-HT2B receptor agonist. BW-723C86 exhibits anxiolytic-like actions. BW-723C86 also causes hyperphagia and reduced grooming in rats. BW-723C86 dilates pulmonary arteries and inhibits liquid meal-induced gastric accommodation[1][2][3][4][5][6].
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BW-723C86 | 98.16% | BW-723C86 is an orally active and a selective 5-HT2B receptor agonist. BW-723C86 exhibits anxiolytic-like actions. BW-723C86 also causes hyperphagia and reduced grooming in rats. BW-723C86 dilates pulmonary arteries and inhibits liquid meal-induced gastric accommodation. | ||||||||||||||||||||
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BW-723C86 (Standard) | ≥98% | BW-723C86 (Standard) is the analytical standard of BW-723C86 (HY-101369). This product is intended for research and analytical applications. BW-723C86 is an orally active and a selective 5-HT2B receptor agonist. BW-723C86 exhibits anxiolytic-like actions. BW-723C86 also causes hyperphagia and reduced grooming in rats. BW-723C86 dilates pulmonary arteries and inhibits liquid meal-induced gastric accommodation. | ||||||||||||||||||||
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References
- [1]. Glusa E, et al. Further evidence that 5-HT-induced relaxation of pig pulmonary artery is mediated by endothelial 5-HT(2B) receptors. Br J Pharmacol. 2000 Jun;130(3):692-8. [Content Brief]
- [2]. Kennett GA, et, al. BW 723C86, a 5-HT2B receptor agonist, causes hyperphagia and reduced grooming in rats. Neuropharmacology. 1997 Feb;36(2):233-9. [Content Brief]
- [3]. Kennett GA, et, al. Anxiolytic-like actions of BW 723C86 in the rat Vogel conflict test are 5-HT2B receptor mediated. Neuropharmacology. 1998 Dec;37(12):1603-10. [Content Brief]
- [4]. Kennett GA, et al. Effects of the 5-HT2B receptor agonist, BW 723C86, on three rat models of anxiety. Br J Pharmacol. 1996 Apr;117(7):1443-8. [Content Brief]
- [5]. Miwa H, et al. Impairment of gastric accommodation induced by water-avoidance stress is mediated by 5-HT2B receptors. Neurogastroenterol Motil. 2016 May;28(5):765-78. [Content Brief]
- [6]. Matsumoto T, et, al. Effect of Equol on Vasocontractions in Rat Carotid Arteries Treated with High Insulin. Biol Pharm Bull. 2019;42(6):1048-1053. [Content Brief]
Keywords
