1616287-82-1
1616287-82-1
Chemical Structure
PF-06726304
- No. CAS: 1616287-82-1
- Formula:C22H21Cl2N3O3
- Molecular Weight:446.33
IUPAC Name: 5,8-dichloro-2-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-7-(3,5-dimethylisoxazol-4-yl)-3,4-dihydroisoquinolin-1(2H)-one
InChIKey: PDKDOPJQPKXNCT-UHFFFAOYSA-N
SMILES: O=C1N(CC2=C(C)C=C(C)NC2=O)CCC3=C1C(Cl)=C(C4=C(C)ON=C4C)C=C3Cl
Biological Activity: PF-06726304 is a potent and selective EZH2 inhibitor. PF-06726304 inhibits wild-type and Y641N mutant EZH2 with Kis of 0.7 and 3.0 nM, respectively. PF-06726304 displays robust antitumor growth activity[1].
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PF-06726304 | 99.71% | PF-06726304 is a potent and selective EZH2 inhibitor. PF-06726304 inhibits wild-type and Y641N mutant EZH2 with Kis of 0.7 and 3.0 nM, respectively. PF-06726304 displays robust antitumor growth activity. | ||||||||||||||||||||
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References
Keywords
