1620389-76-5
Chemical Structure
CQPQGLAKC
- CAS No.: 1620389-76-5
- Formula:C38H66N12O12S2
- Molecular Weight:947.13
InChIKey: HUVFHCQPJQNUCK-APGJSSKUSA-N
SMILES: O=C(N[C@@H](CCC(N)=O)C(N1[C@@H](CCC1)C(N[C@@H](CCC(N)=O)C(NCC(N[C@@H](CC(C)C)C(N[C@@H](C)C(N[C@@H](CCCCN)C(N[C@@H](CS)C(O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CS)N
Biological Activity: CQPQGLAKC is a peptide crosslinker and hydrogel component that can be cleaved by MMP. The degradation of CQPQGLAKC is primarily mediated by endogenous MMP-13, with a Km value of 1.10 µM. CQPQGLAKC crosslinks hyaluronic acid hydrogels via Michael-type addition, thereby enabling cell-mediated matrix remodeling and promoting cell survival, proliferation, and endothelial differentiation. CQPQGLAKC can be used in research on rotator cuff tears and ischemic injury[1][2][3][4].
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CQPQGLAKC | CQPQGLAKC is a peptide crosslinker and hydrogel component that can be cleaved by MMP. The degradation of CQPQGLAKC is primarily mediated by endogenous MMP-13, with a Km value of 1.10 µM. CQPQGLAKC crosslinks hyaluronic acid hydrogels via Michael-type addition, thereby enabling cell-mediated matrix remodeling and promoting cell survival, proliferation, and endothelial differentiation. CQPQGLAKC can be used in research on rotator cuff tears and ischemic injury. | |||||||||||||||||||||
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References
- [1]. Natividad-Diaz SL, et al. A combined hiPSC-derived endothelial cell and in vitro microfluidic platform for assessing biomaterial-based angiogenesis. Biomaterials. 2019 Feb;194:73-83.
- [2]. Jha AK, et al. Matrix metalloproteinase-13 mediated degradation of hyaluronic acid-based matrices orchestrates stem cell engraftment through vascular integration. Biomaterials. 2016 May;89:136-47.
- [3]. Pfaff MR, et al. Viscoelastic HyA Hydrogel Promotes Recovery of Muscle Quality and Vascularization in a Murine Model of Delayed Rotator Cuff Repair. Advanced healthcare materials. 2025 Apr;14(10):e2403962.
- [4]. Browne S, et al. TGF-β1/CD105 signaling controls vascular network formation within growth factor sequestering hyaluronic acid hydrogels. PloS one. 2018;13(3):e0194679.
