162706-37-8
Chemical Structure
Elinafide
Synonym(s): LU 79553
- CAS No.: 162706-37-8
- Formula:C31H28N4O4
- Molecular Weight:520.58
IUPAC Name: 2,2'-((propane-1,3-diylbis(azanediyl))bis(ethane-2,1-diyl))bis(1H-benzo[de]isoquinoline-1,3(2H)-dione)
InChIKey: QUNOQBDEVTWCTA-UHFFFAOYSA-N
SMILES: O=C1N(CCNCCCNCCN(C(C2=CC=CC3=CC=CC4=C23)=O)C4=O)C(C5=CC=CC6=CC=CC1=C56)=O
Biological Activity: Elinafide is an anticancer agent with a naphthalimide structure that targets DNA. Elinafide interferes with cell metabolism by inserting a planar ring into the DNA double helix and interacting with enzymes through its side chain.LU-79553 is a DNA-binding topoisomerase II inhibitor. The IC50 value of Elinafide for HT-29 cells is 0.014 μM[1][2].
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Elinafide | 98.02% | Elinafide is an anticancer agent with a naphthalimide structure that targets DNA. Elinafide interferes with cell metabolism by inserting a planar ring into the DNA double helix and interacting with enzymes through its side chain.LU-79553 is a DNA-binding topoisomerase II inhibitor. The IC50 value of Elinafide for HT-29 cells is 0.014 μM. | ||||||||||||||||||||
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References
- [1]. Braña MF, et al. Naphthalimides as anti-cancer agents: synthesis and biological activity. Curr Med Chem Anticancer Agents. 2001;1(3):237-255. [Content Brief]
- [2]. J Gallego, et al. Solution structure and dynamics of a complex between DNA and the antitumor bisnaphthalimide LU-79553: intercalated ring flipping on the millisecond time scale. Biochemistry. 1999 Nov 16;38(46):15104-15. [Content Brief]
