162831-31-4
Chemical Structure
IEM-1754
- CAS No.: 162831-31-4
- Formula:C16H32Br2N2
- Molecular Weight:412.25
IUPAC Name: N1-(((3r,5r,7r)-adamantan-1-yl)methyl)pentane-1,5-diamine dihydrobromide
InChIKey: JMPHTNNJCZDROM-MZHWIIHPSA-N
SMILES: NCCCCCNCC1(C[C@H](C2)C3)C[C@H]3C[C@H]2C1.Br.Br
Biological Activity: IEM-1754, a dicationic adamantane derivative, is a potent blocker of open channels of native ionotropic glutamate receptors including quisqualate-sensitive receptors in insect muscles, NMDAR in cultured rat cortical neurons, and AMPAR in freshly isolated hippocampal cells. IEM-1754 shows anticonvulsant potency in vivo[1][2].
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IEM-1754 | 98.44% | IEM-1754, a dicationic adamantane derivative, is a potent blocker of open channels of native ionotropic glutamate receptors including quisqualate-sensitive receptors in insect muscles, NMDAR in cultured rat cortical neurons, and AMPAR in freshly isolated hippocampal cells. IEM-1754 shows anticonvulsant potency in vivo. | ||||||||||||||||||||
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- [1]. D B Tikhonov, et al. Voltage-dependent block of native AMPA receptor channels by dicationic compounds. Br J Pharmacol. 2000 Jan;129(2):265-74. [Content Brief]
- [2]. Tikhonov DB, et al. Voltage-dependent block of native AMPA receptor channels by dicationic compounds. Br J Pharmacol. 2000 Jan;129(2):265-74.
Keywords
