1635437-39-6
1635437-39-6
Chemical Structure
UMB-32
- CAS No.: 1635437-39-6
- Formula:C21H23N5O
- Molecular Weight:361.44
IUPAC Name: N-(tert-butyl)-2-(4-(3,5-dimethylisoxazol-4-yl)phenyl)imidazo[1,2-a]pyrazin-3-amine
InChIKey: YXPVTKHEWGXKEY-UHFFFAOYSA-N
SMILES: CC(C)(NC1=C(C2=CC=C(C=C2)C3=C(ON=C3C)C)N=C4N1C=CN=C4)C
Biological Activity: UMB-32, a potent, selective BRD4 inhibitor, binds BRD4 with the Kd of 550 nM, and IC50 of 637 nM. UMB-32 also shows potency against TAF1, a bromodomain-containing transcription factor[1].
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UMB-32 | 99.11% | UMB-32, a potent, selective BRD4 inhibitor, binds BRD4 with the Kd of 550 nM, and IC50 of 637 nM. UMB-32 also shows potency against TAF1, a bromodomain-containing transcription factor. | ||||||||||||||||||||
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References
Keywords
