1637637-70-7
1637637-70-7
Chemical Structure
Pelacarsen
Synonym(s): AKCEA-APO(a)-LRx; ISIS 681257; TQJ230
- CAS No.: 1637637-70-7
- Formula:N/A
- Molecular Weight:8636.00
SMILES: [Pelacarsen]
Biological Activity: Pelacarsen (ISIS 681257) is a GalNAc3-conjugated 2′-MOE-modified antisense oligonucleotide. Pelacarsen reduces apo (a)[1][2][3].
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Pelacarsen | 97.75% | Pelacarsen (ISIS 681257) is a GalNAc3-conjugated 2′-MOE-modified antisense oligonucleotide. Pelacarsen reduces apo (a). | ||||||||||||||||||||
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References
- [1]. Yeang C, et al. Effect of Pelacarsen on Lipoprotein(a) Cholesterol and Corrected Low-Density Lipoprotein Cholesterol. J Am Coll Cardiol. 2022 Mar 22;79(11):1035-1046. [Content Brief]
- [2]. Yu RZ, Graham MJ, Post N, et al. Disposition and Pharmacology of a GalNAc3-conjugated ASO Targeting Human Lipoprotein (a) in Mice. Mol Ther Nucleic Acids. 2016;5(5):e317. [Content Brief]
- [3]. Yu RZ, Gunawan R, Post N, et al. Disposition and Pharmacokinetics of a GalNAc3-Conjugated Antisense Oligonucleotide Targeting Human Lipoprotein (a) in Monkeys. Nucleic Acid Ther. 2016;26(6):372-380. [Content Brief]
Keywords
