1638588-92-7
Chemical Structure
Mazisotine
Synonym(s): LY3556050; CNTX-0290
- CAS No.: 1638588-92-7
- Formula:C16H23N3O2
- Molecular Weight:289.37
IUPAC Name: (1R,5S,6r)-N-(2-methyl-1-((3-methylpyridin-2-yl)oxy)propan-2-yl)-3-azabicyclo[3.1.0]hexane-6-carboxamide
InChIKey: PCINBSQTEDBZDB-ITGUQSILSA-N
SMILES: CC(C=CC=N1)=C1OCC(C)(C)NC([C@H]2[C@@]3([H])[C@]2([H])CNC3)=O
Biological Activity: Mazisotine (CNTX-0290) is an orally active, non-opioid somatostatin receptor 4 (SSTR4) agonist with an EC50 of 4.7 nM. Mazisotine exerts significant analgesic effects in various nociceptive (inflammatory, osteoarthritic) and neuropathic pain models. Mazisotine can be used for pain research[1][2].
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Mazisotine | 99.54% | Mazisotine (CNTX-0290) is an orally active, non-opioid somatostatin receptor 4 (SSTR4) agonist with an EC50 of 4.7 nM. Mazisotine exerts significant analgesic effects in various nociceptive (inflammatory, osteoarthritic) and neuropathic pain models. Mazisotine can be used for pain research. | ||||||||||||||||||||
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[1]. Stevens R, Corradini L, Doods H. Preclinical Evaluation of Human Somatostatin Receptor 4 (hSSTR4) Agonist CNTX-0290 for Mixed Pain Conditions. The Journal of Pain. 2019 Apr 1;20(4):S73.
- [2]. Nguyen TH, et al. Diastereoselective Cyclopropanation with Secondary Diazoacetamides to Access endo-Azabicyclo[3.1.0]hexane-6-carboxamides. Org Lett. Published online February 23, 2026. [Content Brief]
Keywords
