16409-13-5
16409-13-5
Chemical Structure
Formycin triphosphate
- CAS No.: 16409-13-5
- Formula:C10H16N5O13P3
- Molecular Weight:507.18
InChIKey: DCMOKHVROIRMGQ-KSYZLYKTSA-N
SMILES: NC1=C2C(C([C@@H]3O[C@H](COP(OP(OP(O)(O)=O)(O)=O)(O)=O)[C@@H](O)[C@H]3O)=NN2)=NC=N1
Biological Activity: Formycin triphosphate is a fluorescent ATP analog. Formycin triphosphate is a competitive inhibitor of chicken liver pyruvate carboxylase with respect to ATP. Formycin triphosphate can be used in research on human colon cancer[1][2][3][4][5][6].
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Formycin triphosphate | Formycin triphosphate is a fluorescent ATP analog. Formycin triphosphate is a competitive inhibitor of chicken liver pyruvate carboxylase with respect to ATP. Formycin triphosphate can be used in research on human colon cancer. | |||||||||||||||||||||
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References
- [1]. Glazer RI, et al. Effects of 8-azaadenosine and formycin on cell lethality and the synthesis and methylation of nucleic acids in human colon carcinoma cells in culture. Biochemical pharmacology. 1982 Oct 15;31(20):3207-14.
- [2]. Ronjat M, et al. Study of the nucleotide binding site of the yeast Schizosaccharomyces pombe plasma membrane H+-ATPase using formycin triphosphate-terbium complex. The Journal of biological chemistry. 1987 Mar 05;262(7):3146-53.
- [3]. Attwood PV, et al. Interaction of formycin A-5'-triphosphate with pyruvate carboxylase. FEBS letters. 1984 Sep 17;175(1):45-50. [Content Brief]
- [4]. Henderson JF, et al. Biochemical effects of formycin, an adenosine analog. Cancer Research. 1967 Apr 1;27(4):715-9.
- [5]. Brinkley SA, et al. Enzymic preparation of the 5'-triphosphates of 2'-deoxytubercidin, 2'-deoxytoyocamycin, and 2'-deoxyformycin and the allosteric effects of these nucleotides on ribonucleotide reductase. Biochemistry. 2002 May 1;17(12).
- [6]. Ikehara M, et al. Synthesis of formycin triphosphate and its incorporation into ribopolynucleotide by DNA‑dependent RNA polymerase. Biochimica et Biophysica Acta. 1968 Jan 29;155(1):82‑90.
