164992-25-0
Chemical Structure
AR-C67085
Synonym(s): AR-C67085MX; PSB 0413; FPL 67085
- CAS No.: 164992-25-0
- Formula:C14H22Cl2N5O12P3S
- Molecular Weight:648.24
IUPAC Name: (((((((2R,3S,4R,5R)-5-(6-amino-2-(propylthio)-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)oxy)(methoxy)phosphoryl)oxy)(hydroxy)phosphoryl)dichloromethyl)phosphonic acid
InChIKey: ZLIAJZQKKBOFJR-WOUKDFQISA-N
SMILES: NC1=NC(SCCC)=NC2=C1N=CN2[C@H]3[C@H](O)[C@H](O)[C@@H](COP(OP(C(Cl)(Cl)P(O)(O)=O)(O)=O)(O)=O)O3
Biological Activity: AR-C67085 (PSB 0413; FPL 67085) is a potent platelet P2T receptor antagonist with an pIC50 value of 8.60. AR-C67085 inhibits ADP-induced platelet aggregation[1][2].
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AR-C67085 | AR-C67085 (PSB 0413; FPL 67085) is a potent platelet P2T receptor antagonist with an pIC50 value of 8.60. AR-C67085 inhibits ADP-induced platelet aggregation. | |||||||||||||||||||||
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- [1]. Humphries RG, et al. A novel series of P2T purinoceptor antagonists: definition of the role of ADP in arterial thrombosis. Trends Pharmacol Sci. 1995 Jun;16(6):179-81. [Content Brief]
- [2]. Ingall AH, et al. Antagonists of the platelet P2T receptor: a novel approach to antithrombotic therapy. J Med Chem. 1999 Jan 28;42(2):213-20. [Content Brief]
Keywords
