16541-19-8
Chemical Structure
6-T-GDP
Synonym(s): 6-Thioguanosine 5'-diphosphate
- CAS No.: 16541-19-8
- Formula:C10H15N5O10P2S
- Molecular Weight:459.27
IUPAC Name: ((2R,3S,4R,5R)-5-(2-amino-6-thioxo-1,6-dihydro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl trihydrogen diphosphate
InChIKey: IUTNWRFYTFZSEK-UUOKFMHZSA-N
SMILES: O[C@@H]1[C@H](O)[C@@H](COP(OP(O)(O)=O)(O)=O)O[C@H]1N(C=N2)C3=C2C(NC(N)=N3)=S
Biological Activity: 6-T-GDP (6-Thioguanosine 5'-diphosphate) is a metabolite of azathioprine. 6-T-GDP can reduce the transcription of inflammatory factors and the expression of cell adhesion molecules by inhibiting the activity of Rac1, thereby inhibiting the migration of leukocytes and the occurrence of tissue inflammation[1].
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6-T-GDP | 6-T-GDP (6-Thioguanosine 5'-diphosphate) is a metabolite of azathioprine. 6-T-GDP can reduce the transcription of inflammatory factors and the expression of cell adhesion molecules by inhibiting the activity of Rac1, thereby inhibiting the migration of leukocytes and the occurrence of tissue inflammation. | |||||||||||||||||||||
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