1655508-14-7
Chemical Structure
Targaprimir-96
- CAS No.: 1655508-14-7
- Formula:C77H102N18O7
- Molecular Weight:1391.75
IUPAC Name: N-(2-((2-((2-amino-2-oxoethyl)((1-(3-(4-(2,6-di-tert-butyl-4-(6-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)phenoxy)butanamido)propyl)-1H-1,2,3-triazol-4-yl)methyl)amino)-2-oxoethyl)(propyl)amino)-2-oxoethyl)-4-(3-(6-(4-methylpiperazin-1-yl)-1H,3'H-
InChIKey: OLEDRJJUXAAJFN-UHFFFAOYSA-N
SMILES: O=C(N)CN(C(CN(C(CN(C(CCCOC1=CC=CC(C2=NC3=CC=C(C4=NC5=CC=C(N6CCN(C)CC6)C=C5N4)C=C3N2)=C1)=O)CCC)=O)CCC)=O)CC7=CN(CCCNC(CCCOC8=C(C(C)(C)C)C=C(C9=NC%10=CC=C(N%11CCN(C)CC%11)C=C%10N9)C=C8C(C)(C)C)=O)N=N7
Biological Activity: Targaprimir-96 is a potent inhibitor of microRNA-96 (miR-96) processing. Targaprimir-96 selectively modulates miR-96 production in cancer cells and triggers apoptosis. Targaprimir-96 binds primary miR-96 (pri-miR-96) with low nanomolar affinity. Targaprimir-96 directly engages pri-miR-96 in breast cancer cells and is ineffective on healthy breast cells[1].
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Targaprimir-96 | Targaprimir-96 is a potent inhibitor of microRNA-96 (miR-96) processing. Targaprimir-96 selectively modulates miR-96 production in cancer cells and triggers apoptosis. Targaprimir-96 binds primary miR-96 (pri-miR-96) with low nanomolar affinity. Targaprimir-96 directly engages pri-miR-96 in breast cancer cells and is ineffective on healthy breast cells. | |||||||||||||||||||||
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