166196-54-9
Chemical Structure
HDGFRP2/PSIP1-IN-1
Synonym(s): 4-(4-Bromo-1H-pyrazol-5-yl)pyridine
- CAS 番号: 166196-54-9
- Formula:C8H6BrN3
- Molecular Weight:224.06
IUPAC Name: 4-(4-bromo-1H-pyrazol-3-yl)pyridine
InChIKey: LKKNQJJSEMQTHQ-UHFFFAOYSA-N
SMILES: BrC1=CNN=C1C2=CC=NC=C2
Biological Activity: HDGFRP2/PSIP1-IN-1 (compound BPP) is a dual inhibitor targeting the PWWP domain of hepatocarcinogenic growth factor-related protein 2 (HDGFRP2) and its homologous protein PSIP1, hinder the development and progression of diffuse intrinsic pontine glioma (DIPG). HDGFRP2/PSIP1-IN-1 binds to HDGFRP2 with a Kd value of 7 μM and a ligand efficiency of 0.47; it binds to the PSIP1 PWWP domain with a Kd value of 27 μM; meanwhile, it has a Kd value of 14 μM for HDGFRP3, indicating its effectiveness as an inhibitor of the HDGFRP2 PWWP subfamily[1].
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HDGFRP2/PSIP1-IN-1 | HDGFRP2/PSIP1-IN-1 (compound BPP) is a dual inhibitor targeting the PWWP domain of hepatocarcinogenic growth factor-related protein 2 (HDGFRP2) and its homologous protein PSIP1, hinder the development and progression of diffuse intrinsic pontine glioma (DIPG). HDGFRP2/PSIP1-IN-1 binds to HDGFRP2 with a Kd value of 7 μM and a ligand efficiency of 0.47; it binds to the PSIP1 PWWP domain with a Kd value of 27 μM; meanwhile, it has a Kd value of 14 μM for HDGFRP3, indicating its effectiveness as an inhibitor of the HDGFRP2 PWWP subfamily. | |||||||||||||||||||||
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