16839-98-8
16839-98-8
Chemical Structure
Noratropine
- CAS No.: 16839-98-8
- Formula:C16H21NO3
- Molecular Weight:275.34
IUPAC Name: (1R,3r,5S)-8-azabicyclo[3.2.1]octan-3-yl 3-hydroxy-2-phenylpropanoate
InChIKey: ATKYNAZQGVYHIB-MCOXGKPRSA-N
SMILES: OCC(C(O[C@@H]1C[C@@H](N2)CC[C@@H]2C1)=O)C3=CC=CC=C3
Biological Activity: Noratropine is a major metabolite of Atropine (HY-B1205). Noratropine can be formed from Atropine via oxidative N-demethylation and can also be isolated from Anthocercis littorea. Atropine is a competitive muscarinic acetylcholine receptor (mAChR) antagonist. Atropine can be used in research on anti-myopia and bradycardia[1][2][3][4].
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Noratropine | Noratropine is a major metabolite of Atropine (HY-B1205). Noratropine can be formed from Atropine via oxidative N-demethylation and can also be isolated from Anthocercis littorea. Atropine is a competitive muscarinic acetylcholine receptor (mAChR) antagonist. Atropine can be used in research on anti-myopia and bradycardia. | |||||||||||||||||||||
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References
- [1]. Evans WC, et al. Distribution of alkaloids in Anthocercis littorea and A. viscosa. Phytochemistry. 1973;12(10):2505-2507.
- [2]. Chen HX, et al. LC-MS for identification and elucidation of the structure of in-vivo and in-vitro metabolites of atropine. Chromatographia. 2007;65:413-418.
- [3]. NADOR K, et al. N-Allyl-noratropine. J Med Pharm Chem. 1961 Jan 10;3:183-5.
- [4]. Wang Z, et al. Indirect competitive enzyme-linked immunosorbent assay based on a broad-spectrum monoclonal antibody for tropane alkaloids detection in pig urine, pork and cereal flours. Food chemistry. 2021 Feb 01;337:127617. [Content Brief]
