172806-21-2
Chemical Structure
Sp-8-Br-PET-cGMPS
- CAS No.: 172806-21-2
- Formula:C18H15BrN5O6PS
- Molecular Weight:540.28
IUPAC Name: 2-bromo-3-((2S,4aR,6R,7R,7aS)-7-hydroxy-2-mercapto-2-oxidotetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl)-6-phenyl-3,5-dihydro-9H-imidazo[1,2-a]purin-9-one
InChIKey: DBYADRPTMRXVDJ-NMPAKYTISA-N
SMILES: O=C1C(N=C(Br)N2[C@H]3[C@H](O)[C@H](O4)[C@@H](CO[P@@]4(S)=O)O3)=C2N=C5N1C=C(C6=CC=CC=C6)N5
Biological Activity: Sp-8-Br-PET-cGMPS is a membrane-permeable PKG agonist and a membrane-permeable inhibitor of retinal-type cGMP-gated ion channels, as well as an activator of cGMP-dependent protein kinases I α and I β. Sp-8-Br-PET-cGMPS is resistant to mammalian cyclic nucleotide-dependent phosphodiesterases, has no metabolic side effects, and is more lipophilic and permeable than Sp-8-pCPT-cGMPS. Sp-8-Br-PET-cGMPS can be used to study the role of cGMP signaling pathways in the nervous system[1].
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Sp-8-Br-PET-cGMPS | Sp-8-Br-PET-cGMPS is a membrane-permeable PKG agonist and a membrane-permeable inhibitor of retinal-type cGMP-gated ion channels, as well as an activator of cGMP-dependent protein kinases I α and I β. Sp-8-Br-PET-cGMPS is resistant to mammalian cyclic nucleotide-dependent phosphodiesterases, has no metabolic side effects, and is more lipophilic and permeable than Sp-8-pCPT-cGMPS. Sp-8-Br-PET-cGMPS can be used to study the role of cGMP signaling pathways in the nervous system. | |||||||||||||||||||||
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