172927-65-0
172927-65-0
Chemical Structure
Sibrafiban
Synonym(s): RO 48-3657
- CAS No.: 172927-65-0
- Formula:C20H28N4O6
- Molecular Weight:420.47
IUPAC Name: ethyl (Z)-2-((1-((4-(N'-hydroxycarbamimidoyl)benzoyl)-L-alanyl)piperidin-4-yl)oxy)acetate
InChIKey: WBNUCLPUOSXSNJ-ZDUSSCGKSA-N
SMILES: O=C(OCC)COC1CCN(C([C@@H](NC(C2=CC=C(/C(N)=N/O)C=C2)=O)C)=O)CC1.[(Z)]
Biological Activity: Sibrafiban (RO 48-3657) is the orally active, nonpeptide, double-proagent of Ro 44-3888 and a selective glycoprotein IIb/IIIa receptor antagonist. Sibrafiban inhibits platelet aggregation[1][2][3].
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Sibrafiban | 99.67% | Sibrafiban (RO 48-3657) is the orally active, nonpeptide, double-proagent of Ro 44-3888 and a selective glycoprotein IIb/IIIa receptor antagonist. Sibrafiban inhibits platelet aggregation. | ||||||||||||||||||||
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Sibrafiban (Standard) | ≥98% | Sibrafiban (Standard) is the analytical standard of Sibrafiban. This product is intended for research and analytical applications. Sibrafiban (RO 48-3657) is the orally active, nonpeptide, double-proagent of Ro 44-3888 and a selective glycoprotein IIb/IIIa receptor antagonist. Sibrafiban inhibits platelet aggregation. | ||||||||||||||||||||
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References
- [1]. M Dooley, et al. Sibrafiban. Drugs. 1999 Feb;57(2):225-30; discussion 231-2. [Content Brief]
- [2]. B Wittke, et al. Pharmacokinetics and pharmacodynamics of sibrafiban alone or in combination with ticlopidine and aspirin. Br J Clin Pharmacol. 2000 Mar;49(3):231-9. [Content Brief]
- [3]. Jeffrey T Billheimer, et al. Effects of glycoprotein IIb/IIIa antagonists on platelet activation: development of a transfer method to mimic peak to trough receptor occupancy. Thromb Res. 2002 Sep 15;107(6):303-17. [Content Brief]
