17511-50-1
17511-50-1
Chemical Structure
UA8967
- CAS No.: 17511-50-1
- Formula:C20H23N3
- Molecular Weight:305.42
IUPAC Name: 3-((4-benzylpiperazin-1-yl)methyl)-1H-indole
InChIKey: YHZKIEWEQQRAHY-UHFFFAOYSA-N
SMILES: C1(CN2CCN(CC2)CC3=CNC4=C3C=CC=C4)=CC=CC=C1
Biological Activity: UA8967 is a membrane-active antitumor agent. UA8967 exhibits enhanced cytotoxicity against cancer cells harboring a deletion of the tumor suppressor gene DPC4. By disrupting the integrity of the cytoplasmic membrane, UA8967 triggers early caspase-independent autophagy and ultimately leads to non-apoptotic cell lytic death. UA8967 can be used in research on colon cancer and pancreatic cancer[1].
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UA8967 | UA8967 is a membrane-active antitumor agent. UA8967 exhibits enhanced cytotoxicity against cancer cells harboring a deletion of the tumor suppressor gene DPC4. By disrupting the integrity of the cytoplasmic membrane, UA8967 triggers early caspase-independent autophagy and ultimately leads to non-apoptotic cell lytic death. UA8967 can be used in research on colon cancer and pancreatic cancer. | |||||||||||||||||||||
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