1770789-37-1
1770789-37-1
Chemical Structure
Olinone
- CAS No.: 1770789-37-1
- Formula:C17H21N3O2
- Molecular Weight:299.37
IUPAC Name: N-(4-(1-oxo-1,2,3,4-tetrahydro-5H-pyrido[4,3-b]indol-5-yl)butyl)acetamide
InChIKey: RYVLOOXFFIFQEN-UHFFFAOYSA-N
SMILES: CC(NCCCCN1C(CCN2)=C(C2=O)C3=C1C=CC=C3)=O
Biological Activity: Olinone is a selective BRD4 BrD1 inhibitor[1]. Olinone accelerates the progression of mouse primary oligodendrocyte progenitors toward differentiation[2].
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Olinone | Olinone is a selective BRD4 BrD1 inhibitor. Olinone accelerates the progression of mouse primary oligodendrocyte progenitors toward differentiation. | |||||||||||||||||||||
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References
- [1]. Rodríguez Y, et al. In silico design and molecular basis for the selectivity of Olinone toward the first over the second bromodomain of BRD4. Proteins. 2020 Mar;88(3):414-430. [Content Brief]
- [2]. Gacias M, et al. Selective chemical modulation of gene transcription favors oligodendrocyte lineage progression. Chem Biol. 2014 Jul 17;21(7):841-854. [Content Brief]
