177943-33-8
177943-33-8
Chemical Structure
PF-04859989 hydrochloride
- CAS No.: 177943-33-8
- Formula:C9H11ClN2O2
- Molecular Weight:214.65
IUPAC Name: (S)-3-amino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride
InChIKey: WZOBDOKCHIUXAY-FJXQXJEOSA-N
SMILES: O=C1N(O)C2=C(C=CC=C2)C[C@@H]1N.[H]Cl
Biological Activity: PF-04859989 hydrochloride is a brain-penetrant, irreversible kynurenine aminotransferase (KAT) II inhibitor with IC50s of 23 and 263 nM for hKAT II and rKAT II. PF-04859989 hydrochloride is selective for KAT II over human KAT I, KAT III, and KAT IV (IC50s of 22, 11, and >50 μM, respectively)[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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PF-04859989 hydrochloride | 99.90% | PF-04859989 hydrochloride is a brain-penetrant, irreversible kynurenine aminotransferase (KAT) II inhibitor with IC50s of 23 and 263 nM for hKAT II and rKAT II. PF-04859989 hydrochloride is selective for KAT II over human KAT I, KAT III, and KAT IV (IC50s of 22, 11, and >50 μM, respectively). | ||||||||||||||||||||
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