178750-21-5
Chemical Structure
KF24345 free base
- CAS No.: 178750-21-5
- Formula:C31H38N6O5
- Molecular Weight:574.67
IUPAC Name: 3-(1-(6,7-diethoxy-2-morpholinoquinazolin-4-yl)piperidin-4-yl)-1,6-dimethylquinazoline-2,4(1H,3H)-dione
InChIKey: MXOWYPVUVPQDNZ-UHFFFAOYSA-N
SMILES: O=C(N(C1=C(C2=O)C=C(C=C1)C)C)N2C3CCN(CC3)C4=C5C=C(C(OCC)=CC5=NC(N6CCOCC6)=N4)OCC
Biological Activity: KF24345 free base is an orally active adenosine uptake inhibitor. KF24345 free base inhibits adenosine uptake by human, mouse, rabbit and hamster erythrocytes with IC50 values of 59.5, 130.1, 104.2 and 30.9 nM, respectively. KF24345 free base has anti-inflammatory activity and can inhibit LPS-induced TNF-α production and leukopenia in mice[1].
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KF24345 free base | KF24345 free base is an orally active adenosine uptake inhibitor. KF24345 free base inhibits adenosine uptake by human, mouse, rabbit and hamster erythrocytes with IC50 values of 59.5, 130.1, 104.2 and 30.9 nM, respectively. KF24345 free base has anti-inflammatory activity and can inhibit LPS-induced TNF-α production and leukopenia in mice. | |||||||||||||||||||||
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Keywords
