1807988-46-0
1807988-46-0
Chemical Structure
IITZ-02
- CAS. Nr.: 1807988-46-0
- Formula:C27H26N8O2
- Molecular Weight:494.55
SMILES: COC(C=C1)=CC=C1NC2=NC(N3CCOCC3)=NC(NC4=CC=C(C5=NC6=C(N5)C=CC=C6)C=C4)=N2
Biological Activity: IITZ-02 is a lysosomotropic Autophagy inhibitor. IITZ-02 enhances autophagosome accumulation but inhibits autophagosomal degradation by impairing lysosomal function, finally inducing the inhibition of autophagy. IITZ-02 abolishes mitochondrial membrane potential and induces apoptosis through the mitochondria-mediated pathway. IITZ-02 has a potent antitumor activity in MDA-MB-231 xenograft mouse models. IITZ-02 can be used for cancers research[1].
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IITZ-02 | 96.51% | IITZ-02 is a lysosomotropic Autophagy inhibitor. IITZ-02 enhances autophagosome accumulation but inhibits autophagosomal degradation by impairing lysosomal function, finally inducing the inhibition of autophagy. IITZ-02 abolishes mitochondrial membrane potential and induces apoptosis through the mitochondria-mediated pathway. IITZ-02 has a potent antitumor activity in MDA-MB-231 xenograft mouse models. IITZ-02 can be used for cancers research. | ||||||||||||||||||||
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