181137-41-7
Chemical Structure
SKP-451
- CAS No.: 181137-41-7
- Formula:C17H18N2O6
- Molecular Weight:346.33
InChIKey: NJJPKIPOZSWUHV-KRWDZBQOSA-N
SMILES: [O-][N+](C1=CC=C2O[C@](C)(C3OCCO3)C=C(N4C(CCC4)=O)C2=C1)=O
Biological Activity: SKP-451 is an ATP-sensitive potassium (K+) channel agonist. SKP-451 activates the ATP-sensitive K+ channels, promotes the efflux of K+, causes membrane hyperpolarization, and inhibits the influx of Ca2+, thereby relaxing the vascular smooth muscle. SKP-451 relaxs the canine coronary artery, rabbit basilar artery, and vertebral artery. SKP-451 also reduces the mean arterial blood pressure of conscious spontaneously hypertensive rats (SHR). SKP-451 is promising for research of cardiovascular diseases[1].
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SKP-451 | SKP-451 is an ATP-sensitive potassium (K+) channel agonist. SKP-451 activates the ATP-sensitive K+ channels, promotes the efflux of K+, causes membrane hyperpolarization, and inhibits the influx of Ca2+, thereby relaxing the vascular smooth muscle. SKP-451 relaxs the canine coronary artery, rabbit basilar artery, and vertebral artery. SKP-451 also reduces the mean arterial blood pressure of conscious spontaneously hypertensive rats (SHR). SKP-451 is promising for research of cardiovascular diseases. | |||||||||||||||||||||
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Keywords
