1818291-27-8
Chemical Structure
BI-0252
- CAS 番号: 1818291-27-8
- Formula:C30H26Cl2FN3O3
- Molecular Weight:566.45
IUPAC Name: 4-((3S,3'S,3a'S,5'R,6a'S)-6-chloro-3'-(3-chloro-2-fluorophenyl)-1'-(cyclopropylmethyl)-2-oxo-3',3a',4',5',6',6a'-hexahydro-1'H-spiro[indoline-3,2'-pyrrolo[3,2-b]pyrrol]-5'-yl)benzoic acid
InChIKey: CCPUFNJKOGKOOG-AFKAWQRRSA-N
SMILES: ClC1=C(F)C([C@@H]2[C@@]3(C(C=CC(Cl)=C4)=C4NC3=O)N(CC5CC5)[C@@H]6[C@H]2N[C@@H](C7=CC=C(C(O)=O)C=C7)C6)=CC=C1
Biological Activity: BI-0252 is an orally active, selective MDM2-p53 inhibitor with an IC50 of 4 nM. BI-0252 can induce tumor regressions in all animals of a mouse SJSA-1 xenograft, with concomitant induction of the tumor protein p53 (TP53) target genes and markers of apoptosis[1].
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BI-0252 | BI-0252 is an orally active, selective MDM2-p53 inhibitor with an IC50 of 4 nM. BI-0252 can induce tumor regressions in all animals of a mouse SJSA-1 xenograft, with concomitant induction of the tumor protein p53 (TP53) target genes and markers of apoptosis. | |||||||||||||||||||||
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