183284-21-1
183284-21-1
Chemical Structure
Z-Ala-Ala-Asp-CMK
Synonym(s): Z-AAD-CMK
- CAS No.: 183284-21-1
- Formula:C19H24ClN3O7
- Molecular Weight:441.86
InChIKey: RNSFZRYNQRIARX-OBJOEFQTSA-N
SMILES: O=C(OCC1=CC=CC=C1)N[C@@H](C)C(N[C@@H](C)C(N[C@@H](CC(O)=O)C(CCl)=O)=O)=O
Biological Activity: Z-Ala-Ala-Asp-CMK (Z-AAD-CMK) is a selective granzyme B inhibitor. By binding to the active site of granzyme B, Z-Ala-Ala-Asp-CMK blocks its proteolytic function. Z-Ala-Ala-Asp-CMK has anti-inflammatory activity and can be used in the research of inflammatory diseases and cancer[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Z-Ala-Ala-Asp-CMK | 99.08% | Z-Ala-Ala-Asp-CMK (Z-AAD-CMK) is a selective granzyme B inhibitor. By binding to the active site of granzyme B, Z-Ala-Ala-Asp-CMK blocks its proteolytic function. Z-Ala-Ala-Asp-CMK has anti-inflammatory activity and can be used in the research of inflammatory diseases and cancer. | ||||||||||||||||||||
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References
- [1]. Youichi Omoto, et al. Granzyme B is a novel interleukin-18 converting enzyme. J Dermatol Sci. 2010 Aug;59(2):129-35. [Content Brief]
- [2]. Yamamoto T, et al. Enhanced apoptosis of squamous cell carcinoma cells by interleukin-2-activated cytotoxic lymphocytes combined with radiation and anticancer drugs. Eur J Cancer. 2000 Oct;36(15):2007-17. [Content Brief]
