1854026-50-8
1854026-50-8
Chemical Structure
Si-DMA
- CAS No.: 1854026-50-8
- Formula:C35H37ClN2Si
- Molecular Weight:549.22
InChIKey: ZMXHKXBPGUQCQP-UHFFFAOYSA-M
SMILES: CN(C)C1=CC=C2C([Si](C)(C)C(C3=C2C4=CC=C(C(C)=C(C=CC=C5)C5=C6C)C6=C4)=C/C(C=C3)=[N+](C)\C)=C1.[Cl-]
Biological Activity: Si-DMA is a far-red fluorescent singlet oxygen probe (Ex/Em = 640/690 nm). After reacting with singlet oxygen, Si-DMA forms an endoperoxide with a 17-fold fluorescence enhancement. Si-DMA localizes selectively to mitochondria with negligible auto-oxidation. Si-DMA can be used for high spatiotemporal resolution visualization and detection of mitochondrial singlet oxygen in living cells[1][2][3][4].
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Si-DMA | Si-DMA is a far-red fluorescent singlet oxygen probe (Ex/Em = 640/690 nm). After reacting with singlet oxygen, Si-DMA forms an endoperoxide with a 17-fold fluorescence enhancement. Si-DMA localizes selectively to mitochondria with negligible auto-oxidation. Si-DMA can be used for high spatiotemporal resolution visualization and detection of mitochondrial singlet oxygen in living cells. | |||||||||||||||||||||
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References
- [1]. Ishii T, et al. Protein kinase C (PKC) inhibitor Calphostin C activates PKC in a light-dependent manner at high concentrations via the production of singlet oxygen. European journal of pharmacology. 2024 Dec 05;984:177036.
- [2]. Neelambaran N, et al. Exploring a Mitochondria Targeting, Dinuclear Cyclometalated Iridium (III) Complex for Image-Guided Photodynamic Therapy in Triple-Negative Breast Cancer Cells. ACS applied bio materials. 2023 Dec 18;6(12):5776-5788.
- [3]. Murotomi K, et al. Quantitative kinetics of intracellular singlet oxygen generation using a fluorescence probe. Scientific reports. 2020 Jun 30;10(1):10616.
- [4]. Kim S, et al. Far-red fluorescence probe for monitoring singlet oxygen during photodynamic therapy. Journal of the American Chemical Society. 2014 Aug 20;136(33):11707-15.
