186692-44-4
Chemical Structure
(Rac)-Roscovitine
Synonym(s): (Rac)-Seliciclib;(Rac)-CYC202
- CAS No.: 186692-44-4
- Formula:C19H26N6O
- Molecular Weight:354.45
IUPAC Name: 2-((6-(benzylamino)-9-isopropyl-9H-purin-2-yl)amino)butan-1-ol
InChIKey: BTIHMVBBUGXLCJ-UHFFFAOYSA-N
SMILES: CCC(NC1=NC(NCC2=CC=CC=C2)=C3N=CN(C(C)C)C3=N1)CO
Biological Activity: (Rac)-Roscovitine ((Rac)-Seliciclib) is a selective cyclin-dependent kinases (CDKs) inhibitor. (Rac)-Roscovitine binds to the active sites of CDKs competitively with ATP, inhibiting the phosphorylation activity of CDKs. (Rac)-Roscovitine induces apoptosis in cancer cells. (Rac)-Roscovitine is promising for research of cancers or other diseases associated with CDK dysregulation, such as neurodegenerative diseases, cardiac disorders, viral and protozoan infections, glomerulonephritis, and chronic inflammation[1].
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(Rac)-Roscovitine | (Rac)-Roscovitine ((Rac)-Seliciclib) is a selective cyclin-dependent kinases (CDKs) inhibitor. (Rac)-Roscovitine binds to the active sites of CDKs competitively with ATP, inhibiting the phosphorylation activity of CDKs. (Rac)-Roscovitine induces apoptosis in cancer cells. (Rac)-Roscovitine is promising for research of cancers or other diseases associated with CDK dysregulation, such as neurodegenerative diseases, cardiac disorders, viral and protozoan infections, glomerulonephritis, and chronic inflammation. | |||||||||||||||||||||
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Keywords
