186694-45-1
186694-45-1
Chemical Structure
(R)-Eslicarbazepine acetate
Synonym(s): BIA 2-059;(R)-Licarbazepine acetate
- CAS No.: 186694-45-1
- Formula:C17H16N2O3
- Molecular Weight:296.32
IUPAC Name: (R)-5-carbamoyl-10,11-dihydro-5H-dibenzo[b,f]azepin-10-yl acetate
InChIKey: QIALRBLEEWJACW-MRXNPFEDSA-N
SMILES: CC(O[C@H]1C2=CC=CC=C2N(C3=CC=CC=C3C1)C(N)=O)=O
Biological Activity: (R)-Eslicarbazepine acetate (BIA 2-059) is the R-enantiomer of Eslicarbazepine acetate (HY-B0703). Eslicarbazepine acetate is an antiepileptic agent, is a dual a dual Inhibitor of β-Secretase and voltage-gated sodium channel[1][2].
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(R)-Eslicarbazepine acetate | (R)-Eslicarbazepine acetate (BIA 2-059) is the R-enantiomer of Eslicarbazepine acetate (HY-B0703). Eslicarbazepine acetate is an antiepileptic agent, is a dual a dual Inhibitor of β-Secretase and voltage-gated sodium channel. | |||||||||||||||||||||
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References
- [1]. Shaikh S, et, al. Aptiom (eslicarbazepine acetate) as a dual inhibitor of β-secretase and voltage-gated sodium channel: advancement in Alzheimer's disease-epilepsy linkage via an enzoinformatics study. CNS Neurol Disord Drug Targets. 2014;13(7):1258-62. [Content Brief]
- [2]. Alves G, et, al. Stereoselective disposition of S- and R-licarbazepine in mice. Chirality. 2008 Jun;20(6):796-804. [Content Brief]
