1887069-10-4
Chemical Structure
Gamcemetinib
Synonym(s): CC-99677
- CAS No.: 1887069-10-4
- Formula:C22H20ClN5O3S
- Molecular Weight:469.94
IUPAC Name: (R)-3-((2-chloro-5-(ethoxymethyl)pyrimidin-4-yl)oxy)-10-methyl-9,10,11,12-tetrahydro-8H-[1,4]diazepino[5',6':4,5]thieno[3,2-f]quinolin-8-one
InChIKey: PYOQIOLRFIRRSO-LLVKDONJSA-N
SMILES: O=C1C2=C(NC[C@H](N1)C)C3=C(S2)C=CC4=NC(OC5=NC(Cl)=NC=C5COCC)=CC=C34
Biological Activity: Gamcemetinib (CC-99677) is a potent, covalent, and irreversible inhibitor of the mitogen-activated protein (MAP) kinase-activated protein kinase-2 (MK2) pathway in both biochemical (IC50=156.3 nM) and cell based assays (EC50=89 nM). Gamcemetinib is extracted from patent WO2020236636, compound 1[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Gamcemetinib | 99.06% | Gamcemetinib (CC-99677) is a potent, covalent, and irreversible inhibitor of the mitogen-activated protein (MAP) kinase-activated protein kinase-2 (MK2) pathway in both biochemical (IC50=156.3 nM) and cell based assays (EC50=89 nM). Gamcemetinib is extracted from patent WO2020236636, compound 1. | ||||||||||||||||||||
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Keywords
